People face a lot of trouble making money with Google Adsense. The Basic Thing you should have is Real Traffic! And then, Some Activity, i.e Visitors should start sticking to your site without Bouncing. Then Third, Avoiding Ad Blindness to your visitors.So here is some Basic 5 Tips to Make More from Adsense.
1. Try Text Ads if you have A website with Good Content. If it is a Gallery, Try Image And Text Ads, And If its Image + Description Sites, (Not just 1 Image I mean, But Some Images with a Good Description May be) Use Image Only Ads.
2. Place Ads Where people may be concentrated on. Eg: under Title, Above Comment Box, Under Navigation Bars.
3.Ad Block Colors Seems to do great with interaction of Ads and Your site. A New Trend of Color Blending is making your site background the Ad text Color, and Site General Color , the Background of Ads. Try The Contrast Effect to get some Attention.
4. Avoid Using Multiple Ads On the Same Time. The Visitor may find it Irritating, Or he may be clicking your other ads than Adsense which would pay you less.
5. Keyword Rich Content should do great since the ads comes relevant to the topic what you are looking for. More Similar keywords = Right Ads which stays on topic.
Enjoy Adsenseing!! Good Luck.